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Vanda Pharmaceuticals surges as FDA approves Bysanti for bipolar I disorder and schizophrenia

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Vanda Pharmaceuticals (VNDA) is up 40.1% today. Here is some analysis on what might have caused this price movement.

Analysis: VNDA appears to be rallying after Vanda announced U.S. FDA approval of BYSANTI (milsaperidone), a new antipsychotic for bipolar I disorder (manic or mixed episodes) and schizophrenia. The approval expands Vanda’s psychiatry franchise and introduces a second newly approved product in a short period, which investors may be pricing as a meaningful incremental revenue opportunity.

Details:

  • Vanda disclosed FDA approval of BYSANTI (milsaperidone) tablets for the acute treatment of manic or mixed episodes associated with bipolar I disorder and for the treatment of schizophrenia in adults.
  • Vanda stated it expects BYSANTI to be commercially available in the U.S. in Q3 2026.
  • Vanda described BYSANTI as a new chemical entity and highlighted expected protection from regulatory data exclusivity and U.S. patents, with the latest expiring in 2044.
  • The company framed the approval as its second new drug approval in less than two months, following the December 2025 approval of NEREUS (tradipitant) for motion-induced vomiting prevention.
  • Sources:

    PR Newswire, Drugs.com, Nasdaq

    Disclaimer: This price movement analysis was generated with the help of AI. Please double-check the information provided for mistakes.

    $VNDA Hedge Fund Activity

    We have seen 66 institutional investors add shares of $VNDA stock to their portfolio, and 97 decrease their positions in their most recent quarter.

    Here are some of the largest recent moves:

    To track hedge funds' stock portfolios, check out Quiver Quantitative's institutional holdings dashboard.

    $VNDA Government Contracts

    We have seen $171,234 of award payments to $VNDA over the last year.

    Here are some of the awards which we have have seen pay out the most over the last year:

    To track government contracts to publicy traded companies, check out Quiver Quantitative's government contracts dashboard.

    $VNDA Analyst Ratings

    Wall Street analysts have issued reports on $VNDA in the last several months. We have seen 2 firms issue buy ratings on the stock, and 0 firms issue sell ratings.

    Here are some recent analyst ratings:

    • HC Wainwright & Co. issued a "Buy" rating on 02/23/2026
    • Cantor Fitzgerald issued a "Overweight" rating on 10/30/2025

    To track analyst ratings and price targets for $VNDA, check out Quiver Quantitative's $VNDA forecast page.

    $VNDA Price Targets

    Multiple analysts have issued price targets for $VNDA recently. We have seen 4 analysts offer price targets for $VNDA in the last 6 months, with a median target of $12.5.

    Here are some recent targets:

    • Raghuram Selvaraju from HC Wainwright & Co. set a target price of $24.0 on 02/23/2026
    • Chris Howerton from Jefferies set a target price of $7.5 on 12/31/2025
    • Madison El-Saadi from B. Riley Securities set a target price of $14.0 on 12/31/2025
    • Olivia Brayer from Cantor Fitzgerald set a target price of $11.0 on 10/30/2025

    This article is not financial advice. See Quiver Quantitative's disclaimers for more information. Note that there may be inaccuracies due to mistakes in ticker-mapping, and other anomalies.

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