Aptevo Therapeutics Inc. (APVO) reported its second-quarter 2026 business update, highlighting updated Phase 1b/2 RAINIER data for mipletamig in frontline acute myeloid leukemia and a $1.5 million non-dilutive grant for APVO451.
The company ended June 30, 2026, with $9.8 million in cash and cash equivalents and raised $0.6 million during the quarter through its standby equity purchase agreements with Yorkville.
- Mipletamig showed an 87% clinical benefit rate and an 81% remission rate across 31 evaluable unfit frontline AML patients.
- Aptevo said RAINIER entered the final stage of dose optimization, with Phase 1b completion and recommended Phase 2 dose selection targeted for 2026.
- The company received a $1.5 million CARE Fund grant to support IND-enabling work for APVO451.
- Aptevo formed a 50/50 collaboration with Niowave to develop up to three radiopharmaceutical oncology programs.
- Niowave's equity investment represented an initial 7.9% ownership position, with potential ownership of up to 19.99%.
$APVO Hedge Fund Activity
We have seen 1 institutional investors add shares of $APVO stock to their portfolio, and 8 decrease their positions in their most recent quarter.
Here are some of the largest recent moves:
- GSA CAPITAL PARTNERS LLP added 21,539 shares (+inf%) to their portfolio in Q2 2026, for an estimated $95,633
- CITIGROUP INC removed 2,756 shares (-100.0%) from their portfolio in Q1 2026, for an estimated $11,768
- UBS GROUP AG removed 2,715 shares (-78.8%) from their portfolio in Q2 2026, for an estimated $12,054
- GEODE CAPITAL MANAGEMENT, LLC removed 2,516 shares (-18.9%) from their portfolio in Q2 2026, for an estimated $11,171
- TOWER RESEARCH CAPITAL LLC (TRC) removed 92 shares (-100.0%) from their portfolio in Q1 2026, for an estimated $392
- TRADEWINDS CAPITAL MANAGEMENT, LLC removed 13 shares (-100.0%) from their portfolio in Q1 2026, for an estimated $55
- FMR LLC removed 7 shares (-100.0%) from their portfolio in Q1 2026, for an estimated $29
To track hedge funds' stock portfolios, check out Quiver Quantitative's institutional holdings dashboard. You can access data on hedge funds moves and 13F filings through the Quiver Quantitative API 13F endpoint.
