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ContraFect Corporation

CFRX

CFRX: ContraFect Corp is a late clinical-stage biotechnology company focused on the discovery and development of direct lytic agents (DLAs), including lysins and amurin peptides, as new medical modalities for the treatment of life-threatening, antibiotic-resistant infections. Its DLA product candidate, exebacase, is currently being studied in patients with chronic prosthetic joint infections (PJIs) of the knee due to S. aureus or coagulase-negative Staphylococci, and the next product candidate, CF-370, is designed to target a range of gram-negative bacteria, including P. aeruginosa, K. pneumoniae, and A. baumannii, and has demonstrated potent in vivo activity against these pathogens, even against multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains.

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Government lobbying spending instances

  • $20,000 Apr 20, 2010 Issue: None
  • $20,000 Jan 20, 2010 Issue: Defense
  • $20,000 Oct 20, 2009 Issue: Defense
  • $20,000 Jul 20, 2009 Issue: Defense
  • $10,000 Apr 19, 2009 Issue: Defense
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  • Patent Title: Biofilm prevention, disruption and treatment with bacteriophage lysin Dec. 13, 2022
  • Patent Title: Lysin polypeptides active against gram-negative bacteria Aug. 16, 2022
  • Patent Title: Use of lysin to restore/augment antibacterial activity in the presence of pulmonary surfactant of antibiotics inhibited thereby Jun. 14, 2022
  • Patent Title: Antibodies useful in passive influenza immunization, and compositions, combinations and methods for use thereof Feb. 15, 2022
  • Patent Title: Lysin-antimicrobial peptide (amp) polypeptide constructs, lysins, isolated polynucleotides encoding same and uses thereof Apr. 27, 2021
  • Patent Title: Broth microdilution method for evaluating and determining minimal inhibitory concentration of antibacterial polypeptides Dec. 01, 2020
  • Patent Title: Bacteriophage lysin and antibiotic combinations against gram positive bacteria Oct. 27, 2020
  • Patent Title: Lysin polypeptides active against gram-negative bacteria Aug. 18, 2020
  • Patent Title: Antibodies useful in passive influenza immunization, and compositions, combinations and methods for use thereof May. 05, 2020
  • Patent Title: Bacteriophage lysin and antibiotic combinations against gram positive bacteria Feb. 13, 2018
  • Patent Title: Composition and methods based on neutralizing antibodies delivered intranasally for enhanced therapeutic efficacy Aug. 01, 2017
  • Patent Title: Biofilm prevention, disruption and treatment with bacteriophage lysin Nov. 22, 2016
  • Patent Title: Methods and compositions for enhanced immunological therapy and targeting of gram-positive bacteria Apr. 14, 2015
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