aTyr Pharma announces poster presentations on efzofitimod for pulmonary sarcoidosis at the ATS 2025 International Conference.
Quiver AI Summary
aTyr Pharma, Inc. announced it will present three posters at the American Thoracic Society (ATS) 2025 International Conference in San Francisco, showcasing its lead candidate efzofitimod, currently being evaluated in a Phase 3 study for pulmonary sarcoidosis, with topline data expected in Q3 2025. The posters will cover the largest placebo-controlled trial in pulmonary sarcoidosis, real-world treatment patterns, and the incidence and mortality of the disease in the U.S. Efzofitimod, a novel immunomodulator derived from tRNA synthetase, aims to treat interstitial lung disease by resolving inflammation without immune suppression. aTyr is focused on developing effective treatments for diseases with limited options, leveraging its unique discovery platform.
Potential Positives
- aTyr Pharma is presenting three significant posters at the American Thoracic Society (ATS) 2025 International Conference, showcasing research related to its lead therapeutic candidate, efzofitimod.
- The Phase 3 EFZO-FIT™ study on efzofitimod represents the largest placebo-controlled trial in pulmonary sarcoidosis, indicating a major step in the clinical development of a potential treatment for this condition.
- Current ongoing research highlights the need for safer and more effective treatment options in interstitial lung disease (ILD), positioning aTyr as a potential leader in this underserved therapeutic area.
- The press release emphasizes the innovative nature of efzofitimod as a first-in-class biologic immunomodulator, which may offer a unique mechanism of action in treating pulmonary sarcoidosis and related conditions.
Potential Negatives
- Uncertainty regarding the timeline for clinical trial results, with topline data not expected until the third quarter of 2025, which could indicate prolonged investor uncertainty and potential impacts on stock performance.
- Risks associated with the clinical development of efzofitimod, including the possibility of delays in patient enrollment for trials, which could adversely affect the company's ability to deliver timely results.
- The mention of potential challenges in securing additional funding raises concerns about the company's financial stability and ability to sustain its development plans for efzofitimod.
FAQ
What is the EFZO-FIT™ study about?
The EFZO-FIT™ study is a Phase 3 clinical trial investigating efzofitimod for treating pulmonary sarcoidosis.
When will topline data from the study be available?
Topline data from the EFZO-FIT™ study is expected to be released in the third quarter of 2025.
What presentations will aTyr Pharma showcase at the ATS 2025 conference?
aTyr Pharma will present three posters related to efzofitimod, focusing on trial design and real-world treatment patterns.
What is efzofitimod?
Efzofitimod is a first-in-class biologic immunomodulator aimed at treating interstitial lung disease, specifically pulmonary sarcoidosis.
How does efzofitimod work?
Efzofitimod selectively modulates activated myeloid cells, resolving inflammation without suppressing the immune system, preventing fibrosis progression.
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Full Release
Blinded baseline demographics and disease characteristics for ongoing Phase 3 EFZO-FIT™ study of efzofitimod in pulmonary sarcoidosis; topline data from the study expected in the third quarter of 2025
Current epidemiology and treatment practices for pulmonary sarcoidosis in the U.S. based on real-world evidence
SAN DIEGO, Jan. 29, 2025 (GLOBE NEWSWIRE) -- aTyr Pharma, Inc. (Nasdaq: ATYR) (“aTyr” or the “Company”), a clinical stage biotechnology company engaged in the discovery and development of first-in-class medicines from its proprietary tRNA synthetase platform, today announced that the company will present three posters for its lead therapeutic candidate, efzofitimod, at the American Thoracic Society (ATS) 2025 International Conference, which is scheduled to take place May 16 – 21, 2025, in San Francisco, CA.
Preliminary details of the poster presentations appear below. The posters will be available on the aTyr website once presented.
Title:
EFZO-FIT, Largest Placebo-Controlled Trial in Pulmonary Sarcoidosis – Trial Design and Patient Characteristics
Session:
Repair My Broken Lungs
Date and Time:
Monday, May 19, 2025 from 9:15AM – 4:15PM PT
Location:
Moscone Center, San Francisco, CA
Title:
Real-World Treatment Patterns Among Pulmonary Sarcoidosis Patients with Parenchymal Involvement in the US
Session:
The Inflamed Lung: Sarcoidosis and Autoimmune Disease
Date and Time:
Sunday, May 18, 2025 from 9:15AM – 4:15PM PT
Location:
Moscone Center, San Francisco, CA
Title:
Incidence, Prevalence, and Mortality of Pulmonary Sarcoidosis with Parenchymal Involvement in the US
Session:
Current Insights into Risk, Diagnosis, and Treatment of Occupational and Environmental Lung Diseases
Date and Time:
Tuesday, May 20, 2025 from 9:15AM – 4:15PM PT
Location:
Moscone Center, San Francisco, CA
Abo ut Efzofitimod
Efzofitimod is a first-in-class biologic immunomodulator in clinical development for the treatment of interstitial lung disease (ILD), a group of immune-mediated disorders that can cause inflammation and fibrosis, or scarring, of the lungs. Efzofitimod is a tRNA synthetase derived therapy that selectively modulates activated myeloid cells through neuropilin-2 to resolve inflammation without immune suppression and potentially prevent the progression of fibrosis. aTyr is currently investigating efzofitimod in the global Phase 3 EFZO-FIT™ study in patients with pulmonary sarcoidosis, a major form of ILD, and in the Phase 2 EFZO-CONNECT™ study in patients with systemic sclerosis (SSc, or scleroderma)-related ILD. These forms of ILD have limited therapeutic options and there is a need for safer and more effective, disease-modifying treatments that improve outcomes.
About aTyr
aTyr is a clinical stage biotechnology company leveraging evolutionary intelligence to translate tRNA synthetase biology into new therapies for fibrosis and inflammation. tRNA synthetases are ancient, essential proteins that have evolved novel domains that regulate diverse pathways extracellularly in humans. aTyr’s discovery platform is focused on unlocking hidden therapeutic intervention points by uncovering signaling pathways driven by its proprietary library of domains derived from all 20 tRNA synthetases. aTyr’s lead therapeutic candidate is efzofitimod, a first-in-class biologic immunomodulator in clinical development for the treatment of interstitial lung disease, a group of immune-mediated disorders that can cause inflammation and progressive fibrosis, or scarring, of the lungs. For more information, please visit www.atyrpharma.com .
Forward-Looking Statements
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements are usually identified by the use of words such as "anticipate," “believes,” “designed,” “could” “can,” “expects,” “intends,” “may,” “plans,” “potential,” “will,” and variations of such words or similar expressions. We intend these forward-looking statements to be covered by such safe harbor provisions for forward-looking statements and are making this statement for purposes of complying with those safe harbor provisions. These forward-looking statements include, among others, statements regarding the clinical development for efzofitimod, including our expectations with respect to the baseline demographic and patient characteristics, conduct, timing and results of EFZO-FIT™, and the epidemiology and treatment practices for pulmonary sarcoidosis in the U.S. These forward-looking statements also reflect our current views about our plans, intentions, expectations, strategies and prospects, which are based on the information currently available to us and on assumptions we have made. Although we believe that our plans, intentions, expectations, strategies and prospects, as reflected in or suggested by these forward-looking statements, are reasonable, we can give no assurance that the plans, intentions, expectations, strategies or prospects will be attained or achieved. All forward-looking statements are based on estimates and assumptions by our management that, although we believe to be reasonable, are inherently uncertain. Furthermore, actual results may differ materially from those described in these forward-looking statements and will be affected by a variety of risks and factors that are beyond our control including, without limitation, uncertainty regarding geopolitical and macroeconomic events, risks associated with the discovery, development and regulation of efzofitimod, the risk that we or our partners may cease or delay preclinical or clinical development activities for efzofitimod for a variety of reasons (including difficulties or delays in patient enrollment in planned clinical trials), the possibility that existing collaborations could be terminated early, and the risk that we may not be able to raise the additional funding required for our business and product development plans, as well as those risks set forth in our most recent Annual Report on Form 10-K, Quarterly Reports on Form 10-Q and in our other SEC filings. Except as required by law, we assume no obligation to update publicly any forward-looking statements, whether as a result of new information, future events or otherwise.
Contact:
Ashlee Dunston
Sr. Director, Investor Relations and Public Affairs
[email protected]