Sight Sciences, Inc. Reports Positive Outcomes from Key Studies on Interventional Glaucoma Treatment Using OMNI Surgical System

Sight Sciences reports positive outcomes from studies on interventional glaucoma treatments, highlighting reduced eye pressure and medication reliance.

Quiver AI Summary

Sight Sciences, Inc. announced the positive results from three critical studies that highlight the effectiveness of its interventional technologies for treating glaucoma. CEO Paul Badawi emphasized the importance of an interventional approach, noting that the studies showed significant reductions in intraocular pressure (IOP) and decreased reliance on medications for patients. Key findings included a prospective study where patients experienced a mean IOP reduction of over 10 mmHg at both 12 and 24 months after using the OMNI system, with many patients becoming medication-free. Additional research noted that minimally invasive glaucoma surgery combined with cataract surgery yielded better IOP reductions in African American patients compared to cataract surgery alone. These findings underscore the potential of the OMNI system in improving outcomes for various patient groups, particularly those at higher risk for glaucoma.

Potential Positives

The press release highlights significant clinical results demonstrating the effectiveness of the OMNI surgical system in reducing intraocular pressure (IOP) over extended periods, showing a mean reduction of 10.6 mmHg at 24 months and a decrease in medication reliance.
Two-thirds of patients in the study were reported to be medication-free at Month 24, which emphasizes the potential of OMNI technology to enhance patient outcomes significantly.
The findings from nearly 13,000 eyes in a large retrospective study indicate that OMNI provides superior IOP reduction when combined with cataract surgery compared to cataract surgery alone, suggesting a competitive advantage in the market.
The press release emphasizes the importance of interventional treatments for high-risk groups, particularly African American patients, which could help the company position itself as a leader in addressing disparities in glaucoma care.

Potential Negatives

Results may be perceived as selectively reported, as the press release emphasizes positive outcomes while not providing detailed context on potential limitations or adverse outcomes related to the studies.
The inclusion of forward-looking statements and cautionary disclaimers may create uncertainty about the reliability of the clinical efficacy claims made regarding their products.
The focus on specific patient demographics, like African American individuals, may imply that outcomes are not universally applicable, raising concerns about the generalizability of the study results.

FAQ

What are the key findings from Sight Sciences' recent glaucoma studies?

Recent studies show that the OMNI system significantly reduces intraocular pressure and medication dependence in glaucoma patients over 24 to 36 months.

How does OMNI impact intraocular pressure in glaucoma patients?

Patients using OMNI experienced a mean reduction of 10.6 mmHg in intraocular pressure at 24 months, along with decreased medication use.

What are the benefits of interventional glaucoma treatments?

Interventional treatments like OMNI help reduce reliance on medication and effectively lower intraocular pressure in at-risk patient populations.

Who are the notable contributors to the glaucoma research studies?

Key contributors include experts from hospitals and universities such as Duke University, Stanford University, and various eye surgery centers.

What is the significance of the studies for African American glaucoma patients?

The studies highlight the effectiveness of OMNI particularly for African American patients, who are often diagnosed at later disease stages.

Disclaimer: This is an AI-generated summary of a press release distributed by GlobeNewswire. The model used to summarize this release may make mistakes. See the full release here.

$SGHT Insider Trading Activity

$SGHT insiders have traded $SGHT stock on the open market 20 times in the past 6 months. Of those trades, 9 have been purchases and 11 have been sales.

Here’s a breakdown of recent trading of $SGHT stock by insiders over the last 6 months:

STAFFAN ENCRANTZ has made 9 purchases buying 317,496 shares for an estimated $1,210,121 and 0 sales.
ALISON BAUERLEIN (Chief Financial Officer) has made 0 purchases and 3 sales selling 52,274 shares for an estimated $190,186.
PAUL BADAWI (President and CEO) has made 0 purchases and 2 sales selling 48,078 shares for an estimated $179,773.
JEREMY B. HAYDEN (Chief Legal Officer) has made 0 purchases and 2 sales selling 18,891 shares for an estimated $70,054.
DAVID BADAWI (Chief Technology Officer) has made 0 purchases and 2 sales selling 11,712 shares for an estimated $43,432.
MATTHEW LINK (Chief Commercial Officer) sold 4,889 shares for an estimated $20,035
BRENTON TAYLOR (EVP, Operations & R&D) sold 591 shares for an estimated $1,991

To track insider transactions, check out Quiver Quantitative's insider trading dashboard.

$SGHT Hedge Fund Activity

We have seen 39 institutional investors add shares of $SGHT stock to their portfolio, and 34 decrease their positions in their most recent quarter.

Here are some of the largest recent moves:

MILLENNIUM MANAGEMENT LLC removed 629,352 shares (-92.0%) from their portfolio in Q2 2025, for an estimated $2,599,223
AMERICANA PARTNERS, LLC added 365,901 shares (+42.4%) to their portfolio in Q3 2025, for an estimated $1,258,699
BLACKROCK, INC. added 261,554 shares (+11.4%) to their portfolio in Q2 2025, for an estimated $1,080,218
B. RILEY WEALTH ADVISORS, INC. removed 243,082 shares (-100.0%) from their portfolio in Q2 2025, for an estimated $1,003,928
D. E. SHAW & CO., INC. removed 167,120 shares (-39.7%) from their portfolio in Q2 2025, for an estimated $690,205
SQUAREPOINT OPS LLC removed 166,405 shares (-100.0%) from their portfolio in Q2 2025, for an estimated $687,252
RENAISSANCE TECHNOLOGIES LLC removed 152,251 shares (-25.1%) from their portfolio in Q2 2025, for an estimated $628,796

To track hedge funds' stock portfolios, check out Quiver Quantitative's institutional holdings dashboard.

$SGHT Analyst Ratings

Wall Street analysts have issued reports on $SGHT in the last several months. We have seen 1 firms issue buy ratings on the stock, and 0 firms issue sell ratings.

Here are some recent analyst ratings:

Lake Street issued a "Buy" rating on 10/21/2025

To track analyst ratings and price targets for $SGHT, check out Quiver Quantitative's $SGHT forecast page.

$SGHT Price Targets

Multiple analysts have issued price targets for $SGHT recently. We have seen 4 analysts offer price targets for $SGHT in the last 6 months, with a median target of $5.5.

Here are some recent targets:

Cecilia Furlong from Morgan Stanley set a target price of $6.0 on 11/10/2025
Adam Maeder from Piper Sandler set a target price of $5.0 on 11/07/2025
Frank Takkinen from Lake Street set a target price of $7.0 on 10/21/2025
Joanne Wuensch from Citigroup set a target price of $4.0 on 10/07/2025

Full Release

MENLO PARK, Calif., Nov. 11, 2025 (GLOBE NEWSWIRE) -- Sight Sciences, Inc. (Nasdaq: SGHT) (Sight Sciences, or the Company), an eyecare company focused on developing and commercializing innovative, interventional technologies intended to transform care and improve patients’ lives, announced today the results from three key published manuscripts that further demonstrate the value of an interventional mindset in treating glaucoma.

“We are proud to continuously support the study of interventional glaucoma treatment, especially in highlighting critical groups of patients that may benefit from active surgical interventions. These results demonstrate that when surgeons are given the right solutions, they are able to reduce a patient’s intraocular eye pressure (IOP) and reliance on medication and maintain those reductions over an extended period of time, 24 months or 36 months,” said Paul Badawi, Founder and Chief Executive Officer of Sight Sciences.

The following are notable results from the studies:

In a 24-month prospective study of 18 eyes with medication washout at baseline, 12 and 24 months, of standalone OMNI use, mean baseline IOP of 26.1 mmHg was reduced an average of 9.7mmHg at 12 months and 10.6 mmHg at 24 months (both p<.001), while mean medications were reduced from 1.8 to 0.9 and 0.5 (both p<.001) at months 12 and 24, respectively; Two-thirds of patients were medication-free at Month 24. ¹
In a retrospective, observational study of nearly 13,000 African American eyes (including 12,057 cataract surgery only, 491 iStent inject ^® , 189 Hydrus ^® Microstent, and 91 OMNI – all minimally invasive glaucoma surgery (MIGS) at the time of cataract surgery), IOP reductions were higher in this study’s MIGS plus cataract surgery cohorts than cataract surgery alone; the proportion of patients with a greater than or equal to 20% reduction in IOP from baseline was greatest for OMNI, followed by Hydrus Microstent and iStent inject ²
In a subgroup analysis of 220 eyes that had undergone a standalone OMNI procedure in primary open-angle glaucoma, including mild, moderate and severe patients, and both phakic and pseudophakic eyes, IOP was significantly reduced for up to 3 years regardless of lens status or disease severity. ³

“OMNI continues to deliver results for patients , whether it be patients undergoing cataract surgery, those that have already had cataract surgery and are now pseudophakic, or groups at historically higher risk for glaucoma, as demonstrated by our study,” Dr. Leon Herndon from Durham, NC commented. “It is important to have effective tools such as OMNI that are used especially for mild and moderate patients, and can be utilized in conjunction with a cataract surgery or as a standalone procedure. That is especially true with African American patients, a cohort of patients that are often diagnosed at a later stage of disease.”

Authors and affiliations:

Kenneth Olander, University Eye Specialists, Maryville, TN; Mark J. Gallardo, El Paso Eye Surgeons, El Paso, TX; Thomas W. Samuelson, Minnesota Eye Consultants, Minneapolis, MN; Steven R. Sarkisian, Oklahoma Eye Surgeons, Oklahoma City, OK; Jaime E. Dickerson, Jr., Sight Sciences Inc., Menlo Park, CA; Michael Mbagwu, Stanford University School of Medicine, Stanford, CA; Kristian M. Garcia, Verana Health, San Francisco, CA; Leon Herndon, Duke University Eye Center, Durham, NC; Mark F. Pyfer, Northern Ophthalmic Associates, Jenkintown, PA, and Wills Eye Hospital, Philadelphia, PA; Christine Funke, Barnet, Delaney & Perkins Eye Center, Mesa, AZ; Sameh Mosaed, Gavin Herbert Eye Institute, University of California, Irvine, Irvine, CA; Erin Zwick, Verana Health, San Francisco, CA; Jennifer Toth, Verana Health, San Francisco, CA; Nathan M Radcliffe, Mt Sinai School of Medicine, New York, NY.

Author affiliations listed above should not be understood as product endorsement by the affiliated institutions.

Paper References:

¹ Viscodilation of Schlemm’s Canal and Trabeculotomy for Reducing Intraocular Pressure and Medication Use in Pseudophakic Eyes; Kenneth Olander MD PhD, Mark J Gallardo MD, Thomas W Samuelson MD, Steven R Sarkisian MD, Brian Flowers MD, Jaime E Dickerson Jr PhD MS Journal of Cataract and Refractive Surgery. on-line ahead of print October 17 2025. DOI: 10.1097/j.jcrs.0000000000001800

² Ab Interno Minimally Invasive Glaucoma Surgery Effectiveness in Black Patients: IRIS Registry ^® Study; Michael Mbagwu MD, Kristian M Garcia MPH, Leon Herndon MD, Journal of Glaucoma. 2025 Accepted (Sept 19 2025), in press .

³ Standalone canaloplasty and trabeculotomy using the OMNI surgical system: a subgroup analysis from the American Academy of Ophthalmology IRIS ^® Registry (Intelligent Research in Sight); Mark F Pyfer MD, Christine Funke MD, Sameh Mosaed MD, Erin Zwick PhD, Jennifer Toth PhD, Kristian Garcia MPH, Nathan M Radcliffe MD; Clinical Ophthalmology 2025;19:4043-4052. (published Nov 1 2025)

About Sight Sciences

Sight Sciences is an eyecare technology company focused on developing and commercializing innovative and interventional solutions intended to transform care and improve patients’ lives. Using minimally invasive or non-invasive approaches to target the underlying causes of the world’s most prevalent eye diseases, Sight Sciences seeks to create more effective treatment paradigms that enhance patient care and supplant conventional outdated approaches. The Company’s OMNI ^® Surgical System and OMNI ^® Edge Surgical System are implant-free, minimally invasive glaucoma surgery technologies indicated in the United States to reduce intraocular pressure in adult patients with primary open-angle glaucoma. The OMNI Surgical System is CE Marked for the catheterization and transluminal viscodilation of Schlemm’s canal and cutting of the trabecular meshwork to reduce intraocular pressure in adult patients with open-angle glaucoma. Glaucoma is the world’s leading cause of irreversible blindness. The SION ^® Surgical System is a bladeless, manually operated device used in ophthalmic surgical procedures to excise trabecular meshwork. The Company’s TearCare ^® System is 510(k) cleared in the United States for the application of localized heat therapy in adult patients with evaporative dry eye disease due to meibomian gland disease (MGD), enabling clearance of gland obstructions by physicians to address the leading cause of dry eye disease.

Visit www.sightsciences.com for more information.

Sight Sciences and TearCare are trademarks of Sight Sciences registered in the United States. OMNI and SION are trademarks of Sight Sciences registered in the United States, European Union and other territories. TruSync is a trademark of Sight Sciences.

Hydrus is a registered trademark of Alcon Vision LLC.

iStent inject is a registered trademark of Glaukos Corporation.

Forward-Looking Statements

This press release, together with other statements and information publicly disseminated by the Company, contains certain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. The Company intends such forward-looking statements to be covered by the safe harbor provisions for forward-looking statements contained in the Private Securities Litigation Reform Act of 1995 and includes this statement for purposes of complying with these safe harbor provisions. Any statements made in this press release that are not statements of historical fact, including statements about our beliefs and expectations, are forward-looking statements and should be evaluated as such. These statements often include words such as "anticipate," “expect,” “suggests,” “plan,” “believe,” “intend,” “estimates,” “targets,” “projects,” “should,” “could,” “would,” “may,” “will,” “forecast” and other similar expressions. We base these forward-looking statements on our current expectations, plans and assumptions that we have made in light of our experience in the industry, as well as our perceptions of historical trends, current conditions, expected future developments and other factors we believe are appropriate under the circumstances at such time. Although we believe that these forward-looking statements are based on reasonable assumptions at the time they are made, you should be aware that many factors could affect our business, results of operations and financial condition and could cause actual results to differ materially from those expressed in the forward-looking statements. These statements are not guarantees of future performance or results. These forward-looking statements include, but are not limited to, statements concerning the following: OMNI’s clinical efficacy, including ability to maintain reductions in patients’ IOP and reliance on medication over extended periods of time, and efficacy in different patient populations. These forward-looking statements are subject to and involve numerous risks, uncertainties and assumptions, including those discussed under the caption “Risk Factors” in our filings with the U.S. Securities and Exchange Commission, as may be updated from time to time in subsequent filings, and you should not place undue reliance on these statements. These cautionary statements are made only as of the date of this press release. We undertake no obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by applicable law.

Media contact:
[email protected]

Investor contact:
Philip Taylor
Gilmartin Group
415.937.5406
[email protected]