Schrodinger Inc. (SDGR) Stock Falls on Q4 2025 Earnings

Schrodinger Inc. (SDGR) reported fourth-quarter 2025 total revenue of $87.2 million, down 1.23% year‑over‑year and roughly $2.2 million above the consensus revenue estimate of $85.1 million.

Gross profit declined to $57.3 million (down 10.66% year‑over‑year) while cost of sales rose to $29.9 million (up 23.79% year‑over‑year). The company recorded an operating loss of -$17.2 million (worse by 17.16% year‑over‑year) but reported net income attributable to common shareholders of $32.5 million, a large year‑over‑year swing. Diluted earnings per share was $0.44, versus an estimated -$0.19.

Cash flow from operating activities was -$16.1 million (down 48.28% year‑over‑year), and capital spending remained minimal at -$41,000 (down 95.3% year‑over‑year). The balance sheet showed a stronger cash position with cash and cash equivalents of $237.4 million (up 61.13% year‑over‑year) and total liabilities of $362.1 million (down 9.87% year‑over‑year).

Revenue slightly beat expectations, but year‑over‑year revenue and gross profit declined.

Operating results were pressured, producing an operating loss despite positive net income for the quarter.

EPS materially topped estimates, driven by the net‑income outcome.

Operating cash flow weakened, though the company’s cash balance improved significantly year‑over‑year.

Shares moved lower during the trading session, down 2.89% since market open.

Note: This financials data is sourced from a third-party provider and has not been independently verified by Quiver.

Schrodinger Inc. Insider Trading Activity

Schrodinger Inc. insiders have traded $SDGR stock on the open market 5 times in the past 6 months. Of those trades, 0 have been purchases and 5 have been sales.

Here’s a breakdown of recent trading of $SDGR stock by insiders over the last 6 months:

MARGARET DUGAN (Chief Medical Officer) sold 1,395 shares for an estimated $29,387
ROBERT LORNE ABEL (See Remarks) sold 1,230 shares for an estimated $16,617
KENNETH PATRICK LORTON (EVP, CTO & COO, Software) sold 925 shares for an estimated $12,703
YVONNE TRAN (EVP, CLO & CPO) sold 776 shares for an estimated $10,705
JENNY HERMAN (CAO) sold 752 shares for an estimated $10,370

To track insider transactions, check out Quiver Quantitative's insider trading dashboard.

Schrodinger Inc. Hedge Fund Activity

We have seen 95 institutional investors add shares of Schrodinger Inc. stock to their portfolio, and 143 decrease their positions in their most recent quarter.

Here are some of the largest recent moves:

UBS AM, A DISTINCT BUSINESS UNIT OF UBS ASSET MANAGEMENT AMERICAS LLC removed 9,496,746 shares (-71.9%) from their portfolio in Q4 2025, for an estimated $169,801,818
CADIAN CAPITAL MANAGEMENT, LP removed 3,045,952 shares (-100.0%) from their portfolio in Q3 2025, for an estimated $61,101,797
RUBRIC CAPITAL MANAGEMENT LP removed 1,097,319 shares (-20.8%) from their portfolio in Q4 2025, for an estimated $19,620,063
MILLENNIUM MANAGEMENT LLC removed 573,549 shares (-37.0%) from their portfolio in Q4 2025, for an estimated $10,255,056
MORGAN STANLEY removed 550,732 shares (-31.7%) from their portfolio in Q4 2025, for an estimated $9,847,088
UBS GROUP AG added 489,059 shares (+51.3%) to their portfolio in Q4 2025, for an estimated $8,744,374
ROYAL BANK OF CANADA removed 377,259 shares (-88.0%) from their portfolio in Q4 2025, for an estimated $6,745,390

To track hedge funds' stock portfolios, check out Quiver Quantitative's institutional holdings dashboard.

Schrodinger Inc. Analyst Ratings

Wall Street analysts have issued reports on $SDGR in the last several months. We have seen 3 firms issue buy ratings on the stock, and 0 firms issue sell ratings.

Here are some recent analyst ratings:

TD Cowen issued a "Buy" rating on 01/08/2026
B of A Securities issued a "Buy" rating on 12/15/2025
Keybanc issued a "Overweight" rating on 10/08/2025

To track analyst ratings and price targets for Schrodinger Inc., check out Quiver Quantitative's $SDGR forecast page.

Schrodinger Inc. Price Targets

Multiple analysts have issued price targets for $SDGR recently. We have seen 5 analysts offer price targets for $SDGR in the last 6 months, with a median target of $24.0.

Here are some recent targets:

Scott Schoenhaus from Keybanc set a target price of $25.0 on 01/08/2026
Brendan Smith from TD Cowen set a target price of $24.0 on 01/08/2026
Michael Yee from UBS set a target price of $18.0 on 01/07/2026
Michael Ryskin from B of A Securities set a target price of $24.0 on 12/15/2025
Andrea Newkirk from Goldman Sachs set a target price of $19.0 on 09/30/2025