Intellia Therapeutics reports progress in clinical studies and financial results for Q1 2025, maintaining strong cash reserves.
Quiver AI Summary
Intellia Therapeutics, Inc. announced key operational and financial updates for the first quarter of 2025, highlighting significant progress in its clinical trials. The company is on track to complete enrollment in the global Phase 3 HAELO study for hereditary angioedema (HAE) by the third quarter of 2025 and has dosed the first patient in the Phase 3 MAGNITUDE-2 study for hereditary ATTR amyloidosis with polyneuropathy (ATTRv-PN). Additionally, enrollment in the Phase 3 MAGNITUDE trial for ATTR with cardiomyopathy (ATTR-CM) is advancing ahead of projections. Intellia reported approximately $707.1 million in cash, which is expected to fund operations into the first half of 2027. The company's CEO, John Leonard, expressed optimism about upcoming data presentations and the progress of its CRISPR-based therapies, including NTLA-2002 and nexiguran ziclumeran (nex-z).
Potential Positives
- On track to complete enrollment in the global Phase 3 HAELO study for hereditary angioedema by Q3 2025, demonstrating strong progress in clinical trials.
- Dosed the first patient in the global Phase 3 MAGNITUDE-2 study for hereditary ATTR amyloidosis with polyneuropathy, marking a significant milestone in development.
- Enrollment in the MAGNITUDE trial for ATTR with cardiomyopathy is exceeding projections, indicating robust interest and engagement in their clinical programs.
- Ended Q1 2025 with approximately $707.1 million in cash and equivalents, providing a solid financial runway to fund operations into the first half of 2027.
Potential Negatives
- Cash and cash equivalents decreased significantly from $861.7 million to $707.1 million, raising concerns about the company's financial stability and operational funding.
- Collaboration revenue dropped from $28.9 million in Q1 2024 to $16.6 million in Q1 2025, indicating potential challenges in partnerships and project funding.
- Net loss increased to $114.3 million in Q1 2025 compared to $107.4 million in Q1 2024, reflecting worsening financial performance.
FAQ
What is the goal of the Phase 3 HAELO study?
The Phase 3 HAELO study aims to complete enrollment for hereditary angioedema (HAE) by Q3 2025.
What is nexiguran ziclumeran (nex-z) used for?
Nex-z is an investigational therapy for treating hereditary ATTR amyloidosis with polyneuropathy and cardiomyopathy.
When will data from the Phase 1/2 study of NTLA-2002 be presented?
Additional data from the Phase 1 portion of NTLA-2002 will be presented at EAACI Congress in June 2025.
What is Intellia's financial position as of Q1 2025?
Intellia reported approximately $707.1 million in cash, expected to fund operations into the first half of 2027.
What are the key future milestones for Intellia?
Upcoming milestones include enrollment updates, data presentations, and a planned BLA submission in the second half of 2026.
Disclaimer: This is an AI-generated summary of a press release distributed by GlobeNewswire. The model used to summarize this release may make mistakes. See the full release here.
$NTLA Insider Trading Activity
$NTLA insiders have traded $NTLA stock on the open market 9 times in the past 6 months. Of those trades, 0 have been purchases and 9 have been sales.
Here’s a breakdown of recent trading of $NTLA stock by insiders over the last 6 months:
- JOHN M LEONARD (President and CEO) sold 26,807 shares for an estimated $326,509
- DAVID LEBWOHL (EVP, Chief Medical Officer) sold 9,557 shares for an estimated $116,404
- LAURA SEPP-LORENZINO (EVP, Chief Scientific Officer) sold 8,966 shares for an estimated $109,205
- JAMES BASTA (EVP, General Counsel) sold 7,074 shares for an estimated $86,161
- DEREK HICKS (EVP, Chief Business Officer) sold 6,502 shares for an estimated $79,194
- MICHAEL P DUBE (VP, Chief Accounting Officer) sold 1,372 shares for an estimated $16,710
- ELIANA CLARK (EVP, Chief Technical Officer) sold 679 shares for an estimated $6,104
- MUNA BHANJI has made 0 purchases and 2 sales selling 530 shares for an estimated $4,894.
To track insider transactions, check out Quiver Quantitative's insider trading dashboard.
$NTLA Hedge Fund Activity
We have seen 172 institutional investors add shares of $NTLA stock to their portfolio, and 121 decrease their positions in their most recent quarter.
Here are some of the largest recent moves:
- DEEP TRACK CAPITAL, LP removed 4,950,000 shares (-100.0%) from their portfolio in Q4 2024, for an estimated $57,717,000
- ALLIANCEBERNSTEIN L.P. removed 1,928,469 shares (-87.9%) from their portfolio in Q4 2024, for an estimated $22,485,948
- BALYASNY ASSET MANAGEMENT L.P. added 1,556,433 shares (+207.6%) to their portfolio in Q4 2024, for an estimated $18,148,008
- CITADEL ADVISORS LLC added 1,504,631 shares (+152.1%) to their portfolio in Q4 2024, for an estimated $17,543,997
- UBS GROUP AG added 1,463,336 shares (+525.6%) to their portfolio in Q4 2024, for an estimated $17,062,497
- PICTET ASSET MANAGEMENT HOLDING SA removed 1,394,911 shares (-100.0%) from their portfolio in Q4 2024, for an estimated $16,264,662
- MORGAN STANLEY added 1,238,512 shares (+48.1%) to their portfolio in Q4 2024, for an estimated $14,441,049
To track hedge funds' stock portfolios, check out Quiver Quantitative's institutional holdings dashboard.
$NTLA Analyst Ratings
Wall Street analysts have issued reports on $NTLA in the last several months. We have seen 2 firms issue buy ratings on the stock, and 0 firms issue sell ratings.
Here are some recent analyst ratings:
- H.C. Wainwright issued a "Buy" rating on 03/05/2025
- Oppenheimer issued a "Outperform" rating on 11/11/2024
To track analyst ratings and price targets for $NTLA, check out Quiver Quantitative's $NTLA forecast page.
Full Release
- On track to complete enrollment of the global Phase 3 HAELO study in hereditary angioedema (HAE) in the third quarter of 2025
- Dosed first patient in the global Phase 3 MAGNITUDE-2 study evaluating nexiguran ziclumeran (nex-z) in patients with hereditary ATTR amyloidosis with polyneuropathy (ATTRv-PN)
- Enrollment in the global Phase 3 MAGNITUDE trial of nex-z in patients with ATTR with cardiomyopathy (ATTR-CM) continues to track ahead of projections
- Presenting additional data from the Phase 1 portion of the ongoing Phase 1/2 study of NTLA-2002 in patients with HAE at EAACI Congress in June 2025
- Expect to present longer-term data from both ATTR-CM and ATTRv-PN patients in the Phase 1 study of nex-z in the second half of 2025
- Ended the first quarter with approximately $707.1 million in cash, cash equivalents and marketable securities; Expected to fund operations into the first half of 2027
CAMBRIDGE, Mass., May 08, 2025 (GLOBE NEWSWIRE) -- Intellia Therapeutics, Inc. (NASDAQ:NTLA), a leading clinical-stage gene editing company focused on revolutionizing medicine with CRISPR-based therapies, today reported operational highlights and financial results for the first quarter ended March 31, 2025.
“Intellia is full steam ahead and making excellent progress across its clinical programs,” said Intellia President and Chief Executive Officer John Leonard, M.D. “Two key achievements in the first quarter were dosing the first patients in two of our Phase 3 studies: the HAELO study for hereditary angioedema and the MAGNITUDE-2 study for hereditary ATTR amyloidosis with polyneuropathy. Additionally, our Phase 3 MAGNITUDE study for ATTR with cardiomyopathy continues to enroll rapidly. Upcoming catalysts include longer-term data from the ongoing Phase 1 study of NTLA-2002 at the upcoming EAACI Congress in addition to updated data from the Phase 2 study of NTLA-2002 and longer-term Phase 1 data of nex-z in the second half of 2025.”
First Quarter 2025 and Recent Operational Highlights
Hereditary Angioedema (HAE)
-
NTLA-2002:
NTLA-2002 is a wholly owned, investigational
in vivo
CRISPR-based therapy designed to knock out the
KLKB1
gene in the liver, with the goal of lifelong control of HAE attacks after a single dose.
- Intellia will present additional data from the ongoing Phase 1/2 study in an oral presentation at the European Academy of Allergy and Clinical Immunology (EAACI) Congress 2025 on Sunday, June 15 in Glasgow, United Kingdom. The presentation will include longer-term durability data from patients in the Phase 1 portion of the Phase 1/2 study.
- Enrollment is progressing in the global Phase 3 HAELO study and the Company expects to complete enrollment in the third quarter of 2025.
- Intellia expects to present new and longer-term data from the Phase 2 portion of the ongoing Phase 1/2 study in the second half of 2025. The data will include patients who initially received a 25 mg dose or placebo and were subsequently given the 50 mg dose of NTLA-2002 selected for the Phase 3 study.
-
The Company is on track to submit a Biologics License Application (BLA) in the second half of 2026.
Transthyretin (ATTR) Amyloidosis
-
Nexiguran ziclumeran (nex-z, also known as NTLA-2001):
Nex-z is an investigational
in vivo
CRISPR-based therapy designed to inactivate the
TTR
gene in liver cells, thereby preventing the production of transthyretin (TTR) protein for the treatment of ATTR amyloidosis. Nex-z offers the possibility of halting and reversing the disease by driving a deep, consistent and potentially lifelong reduction in TTR protein after a single dose. Nex-z has been generally well tolerated across all patients and at all dose levels tested. The most common treatment-related adverse events have been mild or moderate infusion reactions; all patients were able to receive the intended dose of nex-z. Intellia leads development and commercialization of nex-z in collaboration with Regeneron Pharmaceuticals, Inc.
-
ATTR Amyloidosis with Cardiomyopathy (ATTR-CM):
- In March, Intellia announced the U.S. Food and Drug Administration (FDA) granted Regenerative Medicine Advanced Therapy (RMAT) to nex-z for the treatment of ATTR-CM.
- Enrollment in the global Phase 3 MAGNITUDE trial is progressing ahead of the Company’s target projections and anticipates enrollment to exceed 550 total patients by year-end.
-
Hereditary ATTR Amyloidosis with Polyneuropathy (ATTRv-PN):
- In April, the Company announced the first patient was randomized and dosed with nex-z in the global Phase 3 MAGNITUDE-2 study. Intellia expects enrollment to be completed in 2026.
- In May, the Company will present data at the European Society of Cardiology Heart Failure (ESC-HF) Congress and Peripheral Nerve Society (PNS) Annual Meeting. At ESC-HF, Intellia will show wildtype vs. variant data in patients with ATTR-CM. At PNS, the Company will present interim Phase 1 extended data in patients with ATTRv-PN.
- Intellia expects to present longer-term data from both ATTR-CM and ATTRv-PN patients in the Phase 1 study in the second half of 2025. The data will include updated measures of clinical efficacy and safety.
-
ATTR Amyloidosis with Cardiomyopathy (ATTR-CM):
Platform Update
-
Intellia is pioneering novel technologies, such as CRISPR-based gene editing technologies and lipid nanoparticle (LNP) delivery technologies, to create highly differentiated, future
in vivo
and
ex vivo
product candidates. The Company’s proprietary platform technologies are being researched and developed to expand therapeutics opportunities to support the mission of transforming lives of people with severe diseases, including the possibility of curative genome editing therapeutics.
Upcoming Events
The Company will participate in the following events during the second quarter of 2025:
- Bank of America Securities Health Care Conference, May 13, Las Vegas
- ESC Heart Failure Congress, May 17, Belgrade
- PNS Annual Meeting, May 18, Edinburgh
- RBC Capital Markets Global Healthcare Conference, May 21, New York
-
EAACI Congress, June 15, Glasgow
First Quarter 2025 Financial Results
- Cash Position : Cash, cash equivalents and marketable securities were $707.1 million as of March 31, 2025, compared to $861.7 million as of December 31, 2024. The decrease in cash, cash equivalents and marketable securities was primarily driven by first quarter operations and approximately $51 million of non-recurring cash payments associated with the Company’s previously announced portfolio prioritization, workforce reduction, and real estate consolidation. The Company’s cash, cash equivalents and marketable securities as of March 31, 2025 are expected to fund operations into the first half of 2027.
- Collaboration Revenue : Collaboration revenue was $16.6 million during the first quarter of 2025, compared to $28.9 million during the first quarter of 2024. The $12.3 million decrease was mainly driven by a decrease in collaboration revenue under the AvenCell license and collaboration agreement.
- R&D Expenses : Research and development (R&D) expenses were $108.4 million during the first quarter of 2025, compared to $111.8 million during the first quarter of 2024. The $3.4 million decrease was primarily driven by employee-related expenses, stock-based compensation, research materials and contracted services offset by an increase in the advancement of our lead programs. Stock-based compensation expense included in R&D expenses was $12.6 million for the first quarter of 2025.
- G&A Expenses : General and administrative (G&A) expenses were $29.0 million during the first quarter of 2025, compared to $31.1 million during the first quarter of 2024. The $2.1 million decrease was primarily related to lower employee-related expenses due to a workforce reduction in January 2025 and lower stock-based compensation, partially offset by increases related to severance expenses recorded in the first quarter. Stock-based compensation expense included in G&A expenses was $9.2 million for the first quarter of 2025.
-
Net Loss
:
Net loss was $114.3 million for the first quarter of 2025, compared to $107.4 million during the first quarter of 2024.
Conference Call to Discuss First Quarter 2025 Results
The Company will discuss these results on a conference call today, Thursday, May 8 at 8 a.m. ET.
To join the call:
- U.S. callers should dial 1-833-316-0545 and international callers should dial 1-412-317-5726, approximately five minutes before the call. All participants should ask to be connected to the Intellia Therapeutics conference call.
- Please visit this link for a simultaneous live webcast of the call.
A replay of the call will be available through the Events and Presentations page of the Investors & Media section on Intellia’s website at intelliatx.com , beginning on May 8 at 12 p.m. ET.
About Intellia Therapeutics
Intellia Therapeutics, Inc. (NASDAQ:NTLA) is a leading clinical-stage gene editing company focused on revolutionizing medicine with CRISPR-based therapies. Since its inception, Intellia has focused on leveraging gene editing technology to develop novel, first-in-class medicines that address important unmet medical needs and advance the treatment paradigm for patients. Intellia’s deep scientific, technical and clinical development experience, along with its people, is helping set the standard for a new class of medicine. To harness the full potential of gene editing, Intellia continues to expand the capabilities of its CRISPR-based platform with novel editing and delivery technologies. Learn more at
intelliatx.com
and follow us
@intelliatx
.
Forward-Looking Statements
This press release contains “forward-looking statements” of Intellia Therapeutics, Inc. (“Intellia” or the “Company”) within the meaning of the Private Securities Litigation Reform Act of 1995. These forward-looking statements include, but are not limited to, express or implied statements regarding Intellia’s beliefs and expectations concerning: the safety, efficacy, success and advancement of its clinical programs for NTLA-2001, also known as nexiguran ziclumeran or “nex-z”, for transthyretin (“ATTR”) amyloidosis and NTLA-2002 for the treatment of hereditary angioedema (“HAE”) pursuant to its clinical trial applications (“CTA”) and investigational new drug application (“IND”) submissions, including the expected timing of data releases from its ongoing clinical trials of nex-z and NTLA-2002, regulatory feedback, regulatory filings, and the initiation, enrollment, dosing and completion of clinical trials, such as the completion of enrollment of the Phase 3 HAELO study in the third quarter of 2025 and the submission of a biologics license application (“BLA”) in the second half of 2026, its ability to enroll the Phase 3 MAGNITUDE study and exceed 550 total enrolled patients by the end of 2025, its ability to enroll the Phase 3 MAGNITUDE-2 study and complete enrollment in 2026, its plans to present new data from the Phase 2 portion of the Phase 1/2 study of NTLA-2002 and longer-term Phase 1 data of nex-z, including updated measures of clinical efficacy and safety, in the second half of 2025, the potential of nex-z to halt and reverse disease by driving a deep, consistent and potentially lifelong reduction in TTR protein after a single dose, and the potential of NTLA-2002 to provide lifelong control of HAE attacks after a single dose; its ability to apply novel technologies, such as CRISPR-based gene editing technologies and lipid nanoparticle delivery technologies, to develop
in vivo
and
ex vivo
product candidates, including its ability to use those technologies to expand therapeutic opportunities and the timing expectations of advancing such product candidates; its ability to optimize the impact of its collaborations on its development programs, including, but not limited to, its collaboration with Regeneron Pharmaceuticals, Inc. (“Regeneron”) and their co-development programs for ATTR amyloidosis; and its growth as a company and expectations regarding its uses of capital, expenses, future accumulated deficit and financial results, including its ability to fund operations into the first half of 2027.
Any forward-looking statements in this press release are based on management’s current expectations and beliefs of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include, but are not limited to: risks related to Intellia’s ability to protect and maintain its intellectual property position; risks related to Intellia’s relationship with third parties, including its contract manufacturers, collaborators, licensors and licensees; risks related to the ability of its licensors to protect and maintain their intellectual property position; uncertainties related to the authorization, initiation and conduct of preclinical and clinical studies and other development requirements for its product candidates, including uncertainties related to regulatory approvals to conduct clinical trials; risks related to the ability to develop and commercialize any one or more of Intellia’s product candidates successfully; risks related to the results of preclinical studies or clinical studies not being predictive of future results in connection with future studies; the risk that clinical study results will not be positive; risks related to the potential delay of planned clinical trials due to regulatory feedback or other developments; and risks related to Intellia’s collaborations with Regeneron, or its other collaborations not continuing or not being successful. For a discussion of these and other risks and uncertainties, and other important factors, any of which could cause Intellia’s actual results to differ from those contained in the forward-looking statements, see the section entitled “Risk Factors” in Intellia’s most recent annual report on Form 10-K, as well as discussions of potential risks, uncertainties, and other important factors in Intellia’s other filings with the Securities and Exchange Commission, including its quarterly report on Form 10-Q. All information in this press release is as of the date of the release, and Intellia undertakes no duty to update this information unless required by law.
INTELLIA THERAPEUTICS, INC.
|
||||||||||||||
CONSOLIDATED STATEMENTS OF OPERATIONS (UNAUDITED)
|
||||||||||||||
(Amounts in thousands, except per share data)
|
||||||||||||||
Three Months ended March 31, | ||||||||||||||
2025 | 2024 | |||||||||||||
Collaboration revenue | $ | 16,627 | $ | 28,935 | ||||||||||
Operating expenses: | ||||||||||||||
Research and development | 108,427 | 111,847 | ||||||||||||
General and administrative | 29,007 | 31,091 | ||||||||||||
Total operating expenses | 137,434 | 142,938 | ||||||||||||
Operating loss | (120,807 | ) | (114,003 | ) | ||||||||||
Other income (expense), net: | ||||||||||||||
Interest income | 8,603 | 12,632 | ||||||||||||
Change in fair value of investments, net | (2,125 | ) | (6,065 | ) | ||||||||||
Total other income, net | 6,478 | 6,567 | ||||||||||||
Net loss | $ | (114,329 | ) | $ | (107,436 | ) | ||||||||
Net loss per share, basic and diluted | $ | (1.10 | ) | $ | (1.12 | ) | ||||||||
Weighted average shares outstanding, basic and diluted | 103,500 | 95,502 | ||||||||||||
INTELLIA THERAPEUTICS, INC. | |||||||||||
CONSOLIDATED BALANCE SHEET DATA (UNAUDITED) | |||||||||||
(Amounts in thousands) | |||||||||||
March 31,
2025 |
December 31,
2024 |
||||||||||
Cash, cash equivalents and marketable securities | $ | 707,100 | $ | 861,730 | |||||||
Total assets | 986,163 | 1,191,015 | |||||||||
Total liabilities | 206,244 | 319,059 | |||||||||
Total stockholders' equity | 779,919 | 871,956 | |||||||||
Intellia Contacts:
Investors:
Brittany Chaves
Senior Manager, Investor Relations
[email protected]
Media:
Matt Crenson
Ten Bridge Communications
[email protected]
[email protected]